Introduction Radical prostatectomy remains a cornerstone in the management of localized prostate cancer. While surgical refinements and nerve-sparing approaches have significantly improved outcomes, erectile dysfunction (ED) continues to be one of the most prevalent and distressing sequelae. For many men, postoperative sexual dysfunction represents not just a physiological challenge but also an existential threat to […]

Introduction Cancer remains one of the greatest medical challenges of our era. While advances in genomics, immunotherapy, and targeted agents have transformed clinical outcomes in select cancers, metastasis and therapeutic resistance continue to drive mortality. The underlying biology of metastasis has been studied for decades, but the last two decades have crystallized one crucial concept: […]

Introduction The steady march of time leaves unmistakable footprints on the human body. While aging is a universal biological process, its consequences manifest with striking heterogeneity. Among the most insidious features of aging is the gradual rise in chronic low-grade inflammation, a phenomenon termed inflammaging. This persistent inflammatory state is now recognized as a central […]

Introduction Cancer remains one of the greatest medical challenges of our time, not only because of its uncontrolled cell proliferation but also due to its intricate relationship with chronic inflammation. Over the past two decades, research has revealed that inflammation is not a mere bystander but a driver of oncogenesis, tumor progression, metastasis, and therapy […]

Introduction Erectile dysfunction (ED) is often portrayed as an inevitable part of aging, a silent yet pervasive condition that robs men of confidence and intimacy. However, the story is far more complex. ED is not merely a urological inconvenience; it is a sentinel marker of vascular health, psychological well-being, and overall quality of life. In […]

Introduction Erectile dysfunction (ED) following prostate cancer treatment remains one of the most distressing complications for patients and their partners. For men undergoing definitive radiotherapy, whether external beam radiotherapy (EBRT) or brachytherapy, sexual function often deteriorates within months to years of treatment. Reported rates of moderate to severe ED range from 40% to 70% at […]

Introduction: More Than Just a Molecule of Relaxation Cyclic guanosine monophosphate (cGMP) has long been known as a second messenger critical to vascular smooth muscle relaxation, a discovery that ultimately revolutionized the management of erectile dysfunction through the development of sildenafil. Yet the reach of this humble nucleotide extends far beyond facilitating vasodilation. It plays […]

Introduction For decades, Alzheimer’s disease (AD) has stood as one of the most formidable challenges in neurology, robbing millions of their memory, independence, and dignity. Despite decades of research, therapeutic breakthroughs remain sparse, with most approved agents offering only symptomatic relief. Disease-modifying treatments, though eagerly anticipated, continue to disappoint in large-scale trials. Against this backdrop, […]

Intrauterine growth restriction (IUGR) remains one of the most vexing problems in modern obstetrics. Affecting roughly 5–7% of pregnancies, it is not simply a matter of having a “small baby.” Rather, it represents a pathophysiological failure in placental or fetal growth mechanisms, with consequences ranging from preterm birth and neonatal mortality to lifelong metabolic and […]

For more than two decades, sildenafil citrate has been celebrated as the little blue pill that transformed the treatment of erectile dysfunction. Its mechanism—blocking phosphodiesterase type 5 (PDE5) to enhance nitric oxide–cGMP signaling—has been widely studied in vascular and smooth muscle physiology. Yet recent research suggests that sildenafil’s story extends far beyond the bedroom. Intriguingly, […]